Gliomas

Vysis LSI 1p36 / 1q25 and LSI 19q13/19p13 FISH Probe Kit

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Product Name Unit Size Order Number GTIN
Product Description
Results of Hybridization
Product Description
This fluorescence in situ hybridization (FISH) probe is intended to detect deletion of 1p36 and 19q13 chromosome regions.

The Vysis LSI 1p36 SpectrumOrange/1q25 SpectrumGreen Probes are provided in 1 vial as a mixture of a ~435 kb SpectrumOrange-labeled 1p36 probe and a ~618 kb SpectrumGreen-labeled 1q25 probe premixed in hybridization buffer. The LSI 1p36 probe contains sequences that extend from near SHGC‑57243 locus, through the TP73 and MEGF6 genes, and ends at a point telomeric to the MEGF6 locus. The LSI 1q25 probe contains sequences that extend from a point telomeric to the ABL2 gene, through the ABL2 and ANGPTL1 genes, and ends proximally near the SHGC-1322 locus.

The Vysis LSI 19q13 SpectrumOrange/19p13 SpectrumGreen Probes are provided in 1 vial as a mixture of a ~380 kb SpectrumOrange-labeled 19q13 probe and a ~502 kb SpectrumGreen-labeled 19p13 probe premixed in hybridization buffer. The LSI 19p13 probe contains sequences that extend from a point centromeric to the MAN2B1 locus, through MAN2B1, ZNF443 and ZNF44 genes, and ends at a point telomeric to the ZNF44 locus. The LSI 19q13 probe contains sequences that extend from a point telomeric to the CRX locus, through the CRX, GLTSCR2 and GLTSCR1 genes, and ends proximally at a point centromeric to the GLTSCR1 locus.

Results of Hybridization
Vial 1

This probe allows status assessment of the following two chromosome regions: 1p36 and 1q25. In a normal cell hybridized with the LSI 1p36 and LSI 1q25, two orange and two green signals will be observed indicative of two intact copies of chromosome 1. In an abnormal cell with a deletion in the 1p36 region fewer than two orange signals will be observed.

Vial 2

This probe allows status assessment of the following two chromosome regions: 19q13 and 19p13. In a normal cell with two intact copies of chromosome 19, two orange and two green signals will be observed. In an abnormal cell with a deletion in the 19q13 region, fewer than two orange signals will be observed.

Normal images Abnormal images

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