Vysis LSI ATM (11q22.3) SpectrumOrange Probe

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Product Description
Product Description
Vysis LSI ATM (11q22.3) SpectrumOrange DNA probe hybridizes to band 11q22.3 on human chromosome 11. The hybridized probe fluoresces with moderate to bright intensity both in interphase nuclei and on metaphase chromosomes. In interphase nuclei of normal cells, the probe generally appears as two distinct signals. Occasionally, the ATM probe may appear as three or four signals depending upon the condensation of the DNA and the relative distances between chromatids. The signals may also appear diffuse or split. In a normal metaphase, LSI ATM may appear as one or two signals on each chromosome 11.
This probe set allows status assessment of the ATM gene region on chromosome 11q22.3. In a normal cell with two intact copies of the ATM gene region, a two orange signal pattern will be observed.

This probe set allows status assessment of the ATM gene region on chromosome 11q22.3. In an abnormal cell with a deletion in the ATM gene region, fewer than two orange signals will be observed.
Normal Hybridization: Result of the hybridization of the LSI ATM (11q22.3) Probe as observed in a normal interphase cell.
Abnormal Hybridization: Abnormal cell hybridized with the LSI ATM (11q22.3) Probe. The cell in this image shows the one orange signal pattern indicative of a deletion of one copy of the ATM gene region on chromosome 11q22.3.

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