Multiple Myeloma

Vysis LSI 13q34 SpectrumGreen FISH Probe Kit

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Product Description
RESULTS OF HYBRIDIZATION
Product Description

This fluorescence in situ hybridization (FISH) probe is intended to detect the copy number of the LSI 13q34 probe target located at chromosome 13q34.

The approximately 612 kb SpectrumGreen probe contains the complete Lysosomal-associate Membrane Protein (LAMP1) gene and is located at chromosome 13q34 (chr13:112739323-113351436 March 2006 UCSC Browser).

RESULTS OF HYBRIDIZATION

In an abnormal cell that has lost the 13q34 region of chromosome 13, fewer than two green signals will be observed.

In a normal cell with two intact copies of chromosome 13, two green signals will be observed.

Normal Hybridization: Result of the hybridization of the LSI 13q34 Probe as observed in a normal interphase cell.
Abnormal Hybridization: Abnormal cell hybridized with the LSI 13q34 Probe. The cell in this image shows deletion of one copy of the 13q34 region of chromosome 13 as indicated by the single green signal.

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