Non-Hodgkins Lymphoma

Vysis LSI BIRC3/MALT1 DF FISH Probe Kit

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Product Description
RESULTS OF HYBRIDIZATION
Product Description

The Vysis BIRC3/MALT1 DF FISH Probe Kit is intended to detect the t(11;18) (q21;q21) reciprocal translocation involving the BIRC3 (also know as API2) and MALT1 gene regions using the fluorescence in situ hybridization (FISH) technique.

The SpectrumOrange probe spans approximately 670 kb (chr18:54220804-54891192; March 2006 assembly) and covers the MALT1 gene region. The approximately 932 kb (chr11:101247706-102179265; March 2006 assembly) SpectrumGreen probe spans the BIRC3 gene region..

RESULTS OF HYBRIDIZATION

In a normal cell that lacks the t(11;18)(q21;q21) translocation, a two orange, two green signal pattern will be observed reflecting the two intact copies of MALT1 and BIRC3, respectively.

In an abnormal cell containing the t(11;18)(q21;q21) translocation, a one orange (MALT1), one green (BIRC3), and two fusion (BIRC3/MALT1 and MALT1/ BIRC3) signal pattern will be observed. Some samples containing the t(11;18) may display signal patterns differently than the one orange, one green, and two fusions.

Normal Hybridization: Result fo the hybridization of the LSI BIRC3/MALT1 Dual Color Dual Fusion Probes as observed in normal interphase cells.
Abnormal Hybridization: An abnormal cell hybridized with the LSI BIRC3/MALT1 Dual Color Dual Fusion Probes. The cell in this image shows the one orange, one green and two fusion signal pattern indicative of the t(11;18)(q21;q21) translocation.

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