- Vysis FISH
- Abbott REAL-TIME PCR
- Ordering Information
Product Name | Unit Size | Order Number | GTIN |
This fluorescence in situ hybridization (FISH) probe is intended to detect deletion of the LSI CDKN2A (p16) probe target within the 9p21 chromosome region.
Alterations of the 9p21 locus including the tumor suppressor gene CDKN2A (p16) are implicated in different Meningiomas and Gliomas. Studies support the association of CDKN2A homozygous deletion with malignant progression and suggest that it is a marker of worse prognosis in anaplastic oligodendrogliomas. The Vysis LSI CDKN2A SpectrumOrange/CEP 9 SpectrumGreen Probes have been used in several cytogenetic studies to detect losses of the CDKN2A gene. Using this probe set as well as other relevant markers (eg, p53, RB1, 1p36, 19q13, all Vysis FISH probes), Kramar, et al investigated 82 samples from 81 patients with histologically confirmed glial tumors. In a study using the Vysis LSI CDKN2A SpectrumOrange/ CEP 9 SpectrumGreen Probes on 189 confirmed glioblastoma patients less than 50 years old, Korshunov, et al found 9p21 deletion to be correlated with an unfavorable prognosis.
Vysis LSI CDKN2A/CEP 9 Probes are provided in one vial as a mixture of the LSI CDKN2A (p16) probe labeled with SpectrumOrange and the CEP 9 probe labeled with SpectrumGreen. The LSI CDKN2A probe spans approximately 222 kb and contains a number of genes including MTAP, CDKN2A, and CDKN2B. The LSI CDKN2A contains a number of genetic loci including D9S1749, p16 (INK4B), p14 (ARF), D9S1748, p15(INK4B), and D9S1752. The CEP 9 SpectrumGreen probe hybridizes to alpha satellite sequences specific to chromosome 9
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