Vysis D20S108 FISH Probe Kit

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Product Description
RESULTS OF HYBRIDIZATION
Product Description

The Vysis LSI D20S108 fluorescence in situ hybridization (FISH) probe is intended to detect deletions of Vysis LSI D20S108 probe target locus on 20q12.

Acquired deletions of the long arm of chromosome 20 are found in ~4% of patients with a myelodysplastic syndrome (MDS) and in 1 to 2% of patients with acute myeloid leukemia (AML) and myeloproliferative disorders (MPD). Cytogenetic analysis of del(20q) revealed that the deletion is variable in size, with a commonly deleted region (CDR) spanning 20q11.2 to q12. Within the commonly deleted segment lies the SRC oncogene and possibly other tumor suppressor genes. The CDR is defined as a 2.7 Mb segment in MPD and a 2.6 Mb segment in AML/ MDS, with an overlapping region of 1.7 Mb. In a study of 36 MPD, MDS, and AML patients with del(20q), statistical analyses showed that patients with del(20q) as a sole cytogenetic aberration (favorable subgroup) live longer than patients with del(20q) and other chromosomal changes (poor prognosis subgroup). Among patients from MDS, MPD and MDS/MPD groups, Douet-Guilbert et al identified one commonly deleted region in all 38 investigated samples using FISH, including the Vysis LSI D20S108 FISH Probe.

The Vysis LSI D20S108 Probe is an approximately 201 kb SpectrumOrange labeled probe and contains the D20S108 locus located on chromosome 20q12.

RESULTS OF HYBRIDIZATION
In a normal cell hybridized with the LSI D20S108 probe, the expected pattern is the two orange (2O) signal pattern. In an abnormal cell containing the deletion, the one orange (1O) signal pattern will be observed.
Normal Hybridization: LSI D20S108 Single Color Probe hybridized to normal cells showing the two orange (2O) signal pattern.

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