For more information, contact Abbott.
For more information, contact Abbott.
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This fluorescence in situ hybridization (FISH) probe is intended to detect the t(12;21)(p13;q22) that results in the ETV6/RUNX1 fusion.
The LSI ETV6 (TEL)/RUNX1 (AML1) ES Dual Color Translocation Probe Set is a mixture of a SpectrumGreen ETV6 probe and a SpectrumOrange RUNX1 probe. The LSI ETV6 probe begins between exons 3 & 5 and extends toward the 12p telomere for approximately 347 kb. The LSI RUNX1 probe spans the entire RUNX1 gene and is approximately 732 kb.
In a normal nucleus, the expected pattern for a cell hybridized with the LSI TEL/ AML1 ES Dual Color Translocation probe is the two orange (AML1), two green (TEL) (2O2G) signal pattern. In an abnormal cell containing the TEL/AML1 fusion, the expected signal pattern is one green (native TEL), one large orange (native AML1), one smaller orange signal (residual AML1) and one fused orange/ green (yellow) signal. The green native signal may be absent in some instances due to the deletion of the non-translocated TEL allele.
Normal Hybridization: LSI TEL/AML1 ES Dual Color Translocation Probe hybridized to a nucleus lacking the TEL/AML1 fusion gene showing the two orange and two green (2O2G) signal pattern.
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Please be aware that the website you have requested is intended for the residents of a particular country or countries, as noted on that site. As a result, the site may contain information on pharmaceuticals, medical devices and other products or uses of those products that are not approved in other countries or regions.