Multiple Myeloma

Vysis LSI IGH/MAF DF FISH Probe Kit

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Product Description
RESULTS OF HYBRIDIZATION
Product Description

The Vysis IGH/MAF DF FISH Probe Kit is intended to detect the t(14;16)(q32;q23) reciprocal translocation involving the IGH and MAF gene regions.

The SpectrumOrange probe flanks the MAF gene region and is composed of 2 segments that are each approximately 350 kb with an approximately 2.2 Mb gap. The centromeric segment is located at chr16:75729985-76079705 (March 2006 assembly, UCSC Genome Browser) and the telomeric segment is located at chr16:78290003-78635873 (March 2006 assembly, UCSC Genome Browser). The approximately 1.6 Mb SpectrumGreen probe spans the IGH region. (chr14:104736507-106339460; March 2006 assembly, UCSC Genome Browser)

RESULTS OF HYBRIDIZATION

In an abnormal cell containing the t(14;16), one green (IGH), one orange (MAF) and two fusion signal pattern (der (14) and der (16)) may be observed. Some samples containing the t(14;16) may display signal patterns different than one orange, one green and two fusions.

In a normal cell that lacks the t(14;16), a two green and two orange signal pattern will be observed reflecting the two intact copies of IGH and the MAF region respectively. Due to the presence of the ~2.2 Mb gap between the two SpectrumOrange labeled MAF probes, signal splitting of the orange probe may be observed in both normal and abnormal cells.

Normal Hybridization: An interphase cell hybridized with the LSI IGH/MAF Dual Color, Dual Fusion Translocation Probe. The cell shows the two green (IGH), two orange (MAF) signal pattern.
Abnormal Hybridization: An abnormal interphase cell hybridized with the Vysis LSI IGH/CCND1 XT Dual Color Dual Fusion Probes. The cell in this image shows the one orange (CCND1/MYEOV), one green (IGH), two fusion (der (11) and der (14)) signal pattern indicative of a t(11;14).

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