Non-Hodgkins Lymphoma

Vysis LSI MALT1 Break Apart FISH Probe Kit

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Product Description
Results of Hybridization
Product Description

The Vysis LSI MALT1 Break Apart FISH Probe Kit is intended to detect chromosomal rearrangements at the MALT1 locus on chromosome 18q21 using the fluorescence in situ hybridization (FISH) technique.

The approximately 600 kb (chr18:53915334-54515608; March 2006 assembly, UCSC Genome Browser) SpectrumOrange probe lies centromeric to the MALT1 breakpoint region. The approximately 765 kb (chr18:54554621-55319779; March 2006 assembly, UCSC Genome Browser) SpectrumGreen probe lies telomeric to the MALT1 breakpoint region.

Results of Hybridization

In a normal cell that lacks a t(18q21) in the MALT1 gene region, a two fusion signal pattern will be observed reflecting the two intact copies of MALT1.

In an abnormal cell with a t(18q21), a one fusion, one green, one orange signal pattern will be observed.

Normal Hybridization: Result of the hybridization of the Vysis LSI MALT1 Dual Color Break Apart Rearrangement Probe as observed in three normal interphase cells.
Abnormal Hybridization: An abnormal cell hybridized with the Vysis LSI MALT1 Dual Color Break Apart Rearrangement Probe. The cell in this image shows the one fusion, one orange, and one green signal pattern indicative of a rearrangement of one copy of the MALT1 gene region.

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