ACUTE MYELOGENOUS LEUKEMIA (AML)
Vysis LSI PML/RARA Dual Color, Dual Fusion Translocation Probe Kit
For more information, contact Abbott.
For more information, contact Abbott.
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The LSI PML/RARA Dual Color, Dual Fusion Translocation Probe Set is intended to detect the t(15;17)(q22;q12-21) that results in the PML/RARA gene fusion.
It is a mixture of a SpectrumGreen RARA probe and a SpectrumOrange PML probe. The LSI RARA probe is approximately 827 kb in length and spans the RARA gene. The LSI PML target spans the PML gene and is approximately 517 kb. Within the PML probe target, there is a gap of 15 kb in coverage.
In a normal cell that lacks the t(15;17), a two orange and two green signal pattern will be observed reflecting the two intact copies of RARA and PML, respectively.
This probe is provided for those interested in identifying the t(15;17). In an abnormal cell containing the t(15;17), one orange (PML), a one green (RARA), and two fusion (PML/RARA and RARA/PML) signal pattern is observed.
Normal Hybridization: Result of the hybridization of the LSI PML/RARA Dual Color, Dual Fusion Translocation Probe as observed in a normal interphase cell.
Abnormal Hybridization: Abnormal cell hybridized with the LSI PML/RARA Dual Color, Dual Fusion Translocation Probe.
The cell in this image shows the one orange (PML), one green (RARA), two fusion (PML/ RARA and RARA/PML) signal pattern indicative of the t(15;17).
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Please be aware that the website you have requested is intended for the residents of a particular country or countries, as noted on that site. As a result, the site may contain information on pharmaceuticals, medical devices and other products or uses of those products that are not approved in other countries or regions.