Molecular Catalog
Molecular Catalog
Acute Myelogenous Leukemia (AML)

Vysis PML/RARA Single Fusion FISH Probe Kit

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RESULTS OF HYBRIDIZATION
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The Vysis PML/RARA SF FISH Probes are intended to detect the t(15;17) (q22;q21.1) reciprocal translocation involving the PML and RARA gene regions.

The approximately 239 kb (chr15:71877721-72116436; March 2006 assembly, UCSC Genome Browser) SpectrumOrange probe lies centromeric to the PML gene. The approximately 417 kb (chr17:35762877-36180271; March 2006 assembly, UCSC Genome Browser) SpectrumGreen probe lies telomeric to the RARA gene.

RESULTS OF HYBRIDIZATION
In a normal cell, the expected pattern for a nucleus hybridized with the LSI PML/ RARA probe is a two orange and two green (2O2G) signal pattern. In an abnormal cell containing a PML/RARA fusion, the one green (RARA), one orange (PML), and closely adjacent or fused green/orange (yellow) signal pattern (1O1G1F) is observed.
Normal Hybridization: LSI PML/RARA Dual Color Translocation Probe hybridized to a normal nucleus, showing a two orange, two green (2O2G) signal pattern.
  • Vysis FISH
  • Abbott REAL-TIME PCR
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