GLIOMAS
Vysis LSI PTEN/CEP 10 FISH Probe Kit
For more information, contact Abbott.
For more information, contact Abbott.
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This fluorescence in situ hybridization (FISH) probe is intended to detect deletions of the PTEN gene located on chromosome 10q23.
Vysis LSI PTEN SpectrumOrange/CEP 10 SpectrumGreen Probes are provided in 1 vial as a mixture of LSI PTEN (10q23) probe, labeled with SpectrumOrange, and the CEP 10 probe, labeled with SpectrumGreen. The LSI PTEN (10q23) SpectrumOrange Probe is a ~ 368 kb probe that hybridizes to the 10q23 region on chromosome 10 and contains sequences that flank both the 5′ and 3′ ends of the PTEN gene. The CEP 10 SpectrumGreen probe hybridizes to alpha satellite sequences specific to chromosome 10.
In a normal cell with two intact copies of chromosome 10, two green and two orange signals will be observed.
In an abnormal cell with a deletion of the PTEN (10q23) gene region, fewer than two orange signals will be observed.
Normal Hybridization: Result of the hybridization of the Vysis LSI PTEN / CEP 10 Probes as observed in normal interphase cells. (Photo courtesy of Dr. Arie Perry, Washington University.)
Abnormal Hybridization: An abnormal cell hybridized with the Vysis LSI PTEN / CEP 10 Probes. The cell in this image shows the one orange, two green signal pattern indicative of a PTEN (10q23) deletion. (Photo courtesy of Dr. Arie Perry, Washington University.)
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Please be aware that the website you have requested is intended for the residents of a particular country or countries, as noted on that site. As a result, the site may contain information on pharmaceuticals, medical devices and other products or uses of those products that are not approved in other countries or regions.