MICRODELETION SYNDROMES

Vysis Wolf-Hirschhorn Region LSI WHS SpectrumOrange/CEP 4 SpectrumGreen Probes

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PRODUCT NAME UNIT SIZE ORDER NUMBER GTIN


Vysis Wolf-Hirschhorn Region LSI WHS SpectrumOrange/CEP 4 SpectrumGreen Probes hybridize to the band 4p16.3 (SpectrumOrange LSI WHS) and to the centromere, band region 4p11 - q11 (SpectrumGreen CEP 4), of human chromosome 4. The SpectrumOrange LSI WHS probe contains the 3’ segment of the WHSC1 gene and sequences 3’ to the gene that falls within the Wolf-Hirschhorn critical region1. The hybridized probe fluoresces with moderate to bright intensity both in interphase nuclei and on metaphase chromosomes.

Abnormal Hybridization: Metaphase spread containing one chromosome with the CEP 4 SpectrumGreen but without the LSI WHS SpectrumOrange signal.