Vysis LSI TP53 (17p13.1) SpectrumOrange Probe

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Vysis LSI TP53 (17p13.1) SpectrumOrange DNA probe hybridizes to the band 17p13.1 of human chromosome 17. The hybridized probe fluoresces with bright intensity both in interphase nuclei and on metaphase chromosomes. In interphase nuclei of normal cells, the probe generally appears as two distinct signals. Occasionally, the TP53 probe may appear as three or four signals depending upon the condensation of the DNA and the relative distances between chromatids. The signals may also appear diffuse or split. In a normal metaphase, LSI TP53 may appear as one or two signals on each chromosome 17.

Normal Hybridization: LSI p53 Probe hybridized to a normal cell showing the two orange (2O) signal pattern.