Vysis LSI 13 (13q14) SpectrumGreen Probe

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Vysis LSI 13 (13q14) SpectrumGreen DNA probe hybridizes to band 13q14, spanning the RB-1 region of human chromosome 13. The hybridized probe fluoresces with moderate intensity both in interphase nuclei and on metaphase chromosomes. In interphase nuclei of normal cells, the probe generally appears as two distinct signals. It may also appear as three or four signals depending upon the condensation of the DNA and the relative distances between chromatids. The signals may also appear diffuse or split. In a normal metaphase, the probe may appear as one or two signals on each chromosome 13.

Abnormal Hybridization: LSI 13 (13q14) SpectrumGreen hybridized to an amniocyte. Three green signals indicate three copies of chromosome 13