Vysis LSI (13q34) SpectrumGreen Probe

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Product Description
RESULTS OF HYBRIDIZATION
Product Description
Vysis LSI 13q34 SpectrumGreen DNA probe hybridizes to human chromosome 13q34. The hybridized probe fluoresces with moderate to bright intensity both in interphase nuclei and on metaphase chromosomes. In interphase nuclei of normal cells, the probe generally appears as two distinct signals. The probe may also appear as three or four signals, depending upon DNA condensation, and relative distance between chromatids. The signals may also appear as diffuse or split signals. In a normal metaphase, the probe appears as one signal on each chromosome 13.
RESULTS OF HYBRIDIZATION
In an abnormal cell that has lost the 13q34 region of chromosome 13, fewer than two green signals will be observed. In a normal cell with two intact copies of chromosome 13, two green signals will be observed.
Normal Hybridization: Result of the hybridization of the LSI 13q34 Probe as observed in a normal interphase cell.
Abnormal Hybridization: Abnormal cell hybridized with the LSI 13q34 Probe. The cell in this image shows deletion of one copy of the 13q34 region of chromosome 13 as indicated by the single green signal.

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