Vysis LSI 21 SpectrumOrange Probe

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Vysis LSI 21 SpectrumOrange DNA probe hybridizes to the band region 21q22.13 - q22.2 (loci D21S259, D21S341 and D21S342) of human chromosome 21. The hybridized probe fluoresces with moderate to bright intensity both in interphase nuclei and on metaphase chromosomes. In interphase nuclei of normal cells, the probe generally appears as two distinct signals. It may also appear as three or four signals depending upon the condensation of the DNA and the relative distances between chromatids. The signals may also appear diffuse or split. In a normal metaphase, the probe may appear as one or two signals on each chromosome 21.