Vysis LSI Androgen Receptor Gene (Xq12) SpectrumOrange Probe

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Vysis LSI Androgen Receptor Gene (Xq12) SpectrumOrange DNA probe hybridizes to the band Xq12 of the human X chromosome. The hybridized probe fluoresces with bright intensity both in interphase nuclei and on metaphase chromosomes. In interphase nuclei of normal cells, the probe generally appears as one distinct signal (male specimens). It may also appear as two or three signals depending upon the condensation of the DNA and relative distances between chromatids. The signals may also appear diffuse or split. In a normal metaphase, the probe may appear as one or two signals on each X chromosome.

In a normal male cell hybridized with LSI Androgen Receptor Gene (Xq12) Probe, the expected signal pattern is one orange (1O) signal. In a cell harboring amplification of the LSI Androgen Receptor Gene multiple copies of the orange signal will be observed.

Normal Hybridization: LSI Androgen Receptor Gene (Xq12) Probe hybridized to a normal male cell showing the one orange (1O) signal pattern.