Vysis LSI BCR/ABL Dual Color, Dual Fusion Translocation Probe

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Product Description
RESULTS OF HYBRIDIZATION
Product Description
Vysis LSI BCR/ABL Dual Color Dual Fusion Probes hybridize to chromosome 22q11.2 (breakpoint cluster region SpectrumGreen) and to chromosome 9q34 (abl oncogene SpectrumOrange). The hybridized probe fluoresces with moderate to bright intensity both in interphase nuclei and on metaphase chromosomes.
RESULTS OF HYBRIDIZATION
A nucleus lacking the t(9;22) translocation will exhibit the two orange, two green (2O2G) signal pattern. In a nucleus containing a simple balanced t(9;22), one orange and one green signal from the normal 9 and 22 chromosomes and two orange/green (yellow) fusion signals, one each from the derivative 9 and 22 chromosomes, will be observed (1O1G2F). In some instances, deletions may occur 3’ of the BCR breakpoint and/or 5’ of the ABL breakpoint resulting in either an ES (extra orange or green) signal pattern or a single fusion pattern.
Abnormal Hybridization: LSI BCR/ABL Dual Color, Dual Fusion Translocation Probe hybridized to a nucleus containing a simple balanced t(9;22). One orange, one green and two orange/green fusion signals are observed (1O1G2F).

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