Vysis LSI CCND1 SpectrumOrange/ CEP 11 SpectrumGreen Probes

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Product Description
Results of Hybridization
Product Description
Vysis LSI CCND1 SpectrumOrange/CEP 11 SpectrumGreen Probes hybridize to band 11q13 (LSI Cyclin D1 SpectrumOrange) and to the centromere, band region 11p11.11-q11, locus D11Z1(CEP 11 SpectrumGreen) of human chromosome 11. The hybridized probe fluoresces with moderate to bright intensity both in interphase nuclei and on metaphase chromosomes.
Results of Hybridization
Hybridization of this probe to interphase nuclei of normal cells is expected to produce two orange and two green signals. The anticipated signal pattern in abnormal cells having a gain of copy number of the CCND1 target without a gain of the CEP 11 target is two green and multiple orange signals. Other patterns may be observed if additional genetic alterations are present.
Normal Hybridization: LSI Cyclin D1 SpectrumOrange and CEP 11 SpectrumGreen hybridization.

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