Vysis LSI PML/RARA Dual Color, Dual Fusion Translocation Probe

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Product Description
Product Description
Vysis LSI PML/RARA Dual Color Dual Fusion Probes hybridizes to chromosome 15q22-24 (PML SpectrumOrange) and chromosome 17q21 (Retinoic Acid Receptor α SpectrumGreen). The hybridized probe fluoresces with moderate to bright intensity both in interphase nuclei and on metaphase chromosomes.
In a normal cell that lacks the t(15;17), a two orange and two green signal pattern will be observed reflecting the two intact copies of RARA and PML, respectively.

This probe is provided for those interested in identifying the t(15;17). In an abnormal cell containing the t(15;17), one orange (PML), a one green (RARA), and two fusion (PML/RARA and RARA/PML) signal pattern is observed.
Normal Hybridization: Result of the hybridization of the LSI PML/RARA Dual Color, Dual Fusion Translocation Probe as observed in a normal interphase cell.
Abnormal Hybridization: Abnormal cell hybridized with the LSI PML/RARA Dual Color, Dual Fusion Translocation Probe.

The cell in this image shows the one orange (PML), one green (RARA), two fusion (PML/ RARA and RARA/PML) signal pattern indicative of the t(15;17).

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