Non-Hodgkins Lymphoma

Vysis LSI BCL2 Break Apart FISH Probe kit

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Product Description
RESULTS OF HYBRIDIZATION
Product Description
The Vysis BCL2 Break Apart FISH Probe Kit is intended to detect chromosomal rearrangements at the BCL2 locus on chromosome 18q21 using the fluorescence in situ hybridization (FISH) technique.

The approximately 608 kb (chr18:59173700-59781786; March 2006 assembly, UCSC Genome Browser)5 SpectrumOrange probe lies telomeric to the BCL2 breakpoint region. The approximately 855 kb (chr18:58058886-58913398; March 2006 assembly, UCSC Genome Browser)5 SpectrumGreen probe lies centromeric to the BCL2 breakpoint region.
RESULTS OF HYBRIDIZATION
The anticipated signal pattern in abnormal cells having a chromosomal breakpoint within the gap between the two probe targets on one chromosome 18 is one orange, one green, and one fusion signal. Other patterns may be observed if additional genetic alterations are present.

Hybridization of this probe to interphase nuclei of normal cells is expected to produce two pair of overlapping, or nearly overlapping, orange and green (yellow fusion) signals.
Normal Hybridization: Normal cell hybridization using the LSI BCL2 Dual Color Break Apart Rearrangement Probe.
Abnormal Hybridization: Abnormal cell hybridization using the LSI BCL2 Dual Color Break Apart Rearrangement Probe.

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