Vysis LSI BCR/ABL ES Dual Color Translocation Probe Kit
For more information, contact Abbott.
For more information, contact Abbott.
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The BCR/ABL ES Dual Color Translocation Probe is intended to detect the t(9;22)(q34;q11.2) and complex or masked variants of t(9;22) that result in the BCR/ABL gene fusion. The probe may be used with metaphase chromosomes or interphase nuclei.
The approximately 671 kb SpectrumOrange ABL1 probe extends from a point centromeric of the arginosuccinate synthase gene (ASS1) to telomeric of the ABL1 gene on chromosome 9. The SpectrumGreen BCR probe begins between exons 13 and 14 (major breakpoint cluster region [M-bcr] exons 3 and 4) and extends toward the chromosome 22 centromere for approximately 287 kb. The BCR probe flanks the expected M-bcr breakpoints, but spans the minor breakpoint cluster region (m-bcr) for t(9;22)(q34;q11.2).
A nucleus lacking the t(9;22) will exhibit a two orange, two green (2O2G) signal pattern. In a nucleus possessing the t(9;22) involving the M-bcr, one green (native BCR), one large orange (native ABL), one smaller orange (ES), and one fused orange/ green signal (5’ BCR/3’ ABL),(2O1G1F) will be observed. Minor breakpoint (m-bcr) signal patterns may appear as one orange, one green, and two fusion signals. In some cells a deletion may occur 5’ of the ABL breakpoint that may reduce the ES pattern to a single fusion pattern.
Abnormal Hybridization: LSI BCR/ABL ES Dual Color Translocation Probe hybridized to a nucleus containing the t(9;22) showing one green (native BCR), one large orange(native ABL), one smaller orange (ES) and one fused orange/green(20IGIF) signal pattern.
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Please be aware that the website you have requested is intended for the residents of a particular country or countries, as noted on that site. As a result, the site may contain information on pharmaceuticals, medical devices and other products or uses of those products that are not approved in other countries or regions.