Vysis LSI BCR/ABL ES Dual Color Translocation Probe Kit

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Product Description
RESULTS OF HYBRIDIZATION
Product Description
The BCR/ABL ES Dual Color Translocation Probe is a mixture of the LSI ABL probe labeled with SpectrumOrange and the LSI BCR probe labeled with SpectrumGreen. The spanning ABL probe is approximately ~671 kb extending from an area centromeric of the ASS gene to well telomeric of the last ABL exon. The SpectrumGreen BCR probe is approximately ~287 kb beginning between BCR exons 13 and 14 (M-bcr exons 2 and 3) and extending well beyond the m-bcr region.
RESULTS OF HYBRIDIZATION
A nucleus lacking the t(9;22) will exhibit a two orange, two green (2O2G) signal pattern. In a nucleus possessing the t(9;22) involving the M-bcr, one green (native BCR), one large orange (native ABL), one smaller orange (ES), and one fused orange/ green signal (5’ BCR/3’ ABL),(2O1G1F) will be observed. Minor breakpoint (m-bcr) signal patterns may appear as one orange, one green, and two fusion signals. In some cells a deletion may occur 5’ of the ABL breakpoint that may reduce the ES pattern to a single fusion pattern.
Abnormal Hybridization: LSI BCR/ABL ES Dual Color Translocation Probe hybridized to a nucleus containing the t(9;22) showing one green (native BCR), one large orange(native ABL), one smaller orange (ES) and one fused orange/green(20IGIF) signal pattern.

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