Vysis LSI PML/RARA Dual Color Single Fusion Probes

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Product Description
RESULTS OF HYBRIDIZATION
Product Description
Vysis LSI PML/RARA Dual Color Single Fusion Probes hybridize to chromosome 15q22-24 (PML SpectrumOrange) and chromosome 17q21 (Retinoic Acid Receptor A SpectrumGreen). This probe is useful for the detection of the translocation t(15;17)(q22;q21). The hybridized probe fluoresces with moderate to bright intensity both in interphase nuclei and on metaphase chromosomes.
RESULTS OF HYBRIDIZATION
In a normal cell, the expected pattern for a nucleus hybridized with the LSI PML/ RARA probe is a two orange and two green (2O2G) signal pattern. In an abnormal cell containing a PML/RARA fusion, the one green (RARA), one orange (PML), and closely adjacent or fused green/orange (yellow) signal pattern (1O1G1F) is observed.
Normal Hybridization: LSI PML/RARA Dual Color Translocation Probe hybridized to a normal nucleus, showing a two orange, two green (2O2G) signal pattern.

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